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[Effects of three intravenous gamma globulin
regimens on Kawasaki disease and relevant coronary complication rates
in pediatric patients: a comparative study]
Zhonghua Yi Xue Za Zhi. 2007 Nov 27;87(44):3119-21.
[Article in Chinese]
DU ZD, Zhao D, DU JB, Lu S, Yi JM, Hou AC, Zhou ZS, Ding GF; Beijing Kawasaki Disease Epidemilogy Study Grou.
Department of Cardiology, Beijing Children's Hospital, Capital Medical University, Beijing 100045, China.
OBJECTIVES:
To compare the effects on Kawasaki disease (KD) of 3 different
intravenous gamma globulin (IVIG) regimens and coronary complication
rates in children with Kawasaki disease (KD). METHODS: The clinical
data of 1052 children with KD treated in 45 hospitals in Beijing from
2000 through 2004, 680 male and 372 female, aged 2 months-13.8 years,
656 (60.1%) undergoing IVIG 2 g/kg for one dose (single dose group),
292 (26.7%) undergoing 1 g.kg(-1).d(-1) for 2 days (2 d group), and 104
(9.5%) undergoing 400 - 600 mg.kg(-1).d(-1) for 4 - 5 d (4 - 5 d group)
in addition of oral administration of aspirin, were analyzed
retrospectively. Echocardiography was used to assess the occurrence of
coronary complications 1 - 2 weeks after onset (acute stage) and 3 - 6
weeks after onset (sub-acute stage).
RESULTS: The rate of IVIG
non-responder of the 2 d group was 20.9%, significantly higher than
those of the single dose group and 4 - 5 d group (9.9% and 8.7%
respectively, both P < 0.01). There were no significant differences
in rates of coronary complication, pericardial effusion, and mitral
regurgitation at the acute stage among the 3 groups (all P > 0.05).
However, the rates of coronary complication and of coronary aneurysm at
the sub-acute stage of the single dose group were 5.1% and 1.6%,
significantly lower than those of the 4 - 5 d group (11.6% and 4.7%)
and 2 d group (9.8% and 5.4%, P = 0.035 - 0.047) were significantly
lower in single dose group (5.1% and 1.6%) as compared to those in 4 -
5 d group and (11.6% and 4.7%) and 2 d group (9.8% and 5.4%) (P = 0.035
- 0.047). CONCLUSION: IVIG 2 g/kg in a single dose has lower rates of
coronary complications and IVIG non-responders in children with KD, and
is recommended for initial KD therapy.
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