PPTA | Immunoglobulin Literature Database
| Rescue treatment for cyclosporine-associated hemolytic-uremic syndrome with intravenous immunoglobul |
|
Rescue treatment for cyclosporine-associated hemolytic-uremic syndrome with intravenous immunoglobulin.
Clin Nephrol. 2006 Jul;66(1):58-62.
Wen YK, Division of Nephrology, Department of Medicine, Changhua Christian, Hospital, 135 Nansiao St., Changhua, 500, Taiwan. This e-mail address is being protected from spambots. You need JavaScript enabled to view it Hemolytic-uremic syndrome (HUS) is a rare complication occurring in solid-organ and bone marrow transplant recipients treated with calcineurin inhibitors cyclosporine or tacrolimus. We report here about a 30-year-old female cadaveric renal transplant recipient receiving cyclosporine who developed HUS in the early post-transplant period. Renal allograft biopsy specimens showed the characteristic features of thrombotic microangiopathy and acute cyclosporine nephrotoxicity. Cyclosporine was discontinued and the patient was switched to tacrolimus in conjunction with plasma exchange. Unfortunately, plasma exchange was interrupted by bleeding complication resulting from placement of double-lumen catheter. Intravenous immunoglobulin (IVIG) was then administrated as an alternative therapy. Hematological resolution occurred promptly and renal function recovered uneventfully. Our presenting case suggests the beneficial effect of IVIG on cyclosporine-associated HUS. |
