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[Intravenous immunoglobulin (GB-0998) for prophylaxis of recurrent acute otitis media and lower resp

Nihon Rinsho Meneki Gakkai Kaishi. 1998 Apr;21(2):70-9.  


[Intravenous immunoglobulin (GB-0998) for prophylaxis of recurrent acute otitis media and lower respiratory tract infection in infancy with IgG 2 deficiency]

[Article in Japanese]

Sakiyama Y, Komiyama A, Shiraki K, Taniguchi N, Torii S, Baba S, Yata J, Matsumoto S.

Department of Pediatrics, School of Medicine, Hokkaido University.

The prophylactic effect of intravenous immunoglobulin (GB-0998) on the recurrent acute otitis media, bronchitis and bronchopneumonia in IgG 2 deficient infants was investigated in a multicenter trial. GB-0998 was administered 6 times every 4 weeks. The doses were 300 mg/kg wt. during the first treatment, followed by 5 doses of 200 mg/kg wt. The results indicated that GB-0998 was effective in the prophylaxis of the recurrent infection of acute otitis media, bronchitis and bronchopneumonia in infancy with IgG 2 deficiency and/or IgG 2 antibody deficiency specific for Streptococcus pneumoniae.

Publication Types:
  • Clinical Trial
  • Multicenter Study

PMID: 9666680 [PubMed - indexed for MEDLINE]