PPTA | Immunoglobulin Literature Database
| Comparison of thrombopoiesis during ITP and HIV-ITP and response to intravenous gammaglobulin treatm |
Comparison of thrombopoiesis during ITP and HIV-ITP and response to intravenous gammaglobulin treatment. Gyongyossy-Issa MI, Bussel JB, Carter CJ, Devine DV. Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC Canada. This e-mail address is being protected from spambots. You need JavaScript enabled to view it Immune thrombocytopenic purpura's diagnosis (ITP) is based on low platelet count and exclusion of clinical conditions rather than a specific diagnostic test. We used the reticulated platelet (RP) assay to study ITP and thrombocytopenia associated with HIV infection (HIV-ITP). Data from 96 ITP and 23 HIV-ITP patients showed low platelet counts (PC) with both high or low %RP suggesting that individuals have different degrees of thrombopoiesis. About 20% of ITP and 46% of HIV-ITP patients had %RP in the 'low' or 'normal' ranges. Grouped by platelet count <30x10(9)/L, 24% ITP and 36% HIV-ITP patients had 'low' to 'normal' %RP. The patient population did not show correlation between PC and %RP, but individuals showed an inverse relationship. Within a week of receiving IVIG, 18 ITP and 9 HIV-ITP patients' PC increased, %RP decreased. Patients with %RP measured within 24 h of IVIG treatment had lower %RP than expected, suggesting dilution by an older platelet population. ITP and HIV-ITP patients' responses to i.v. gammaglobulins were similar. Thrombopoietin levels of ITP patients did not correlate with PC, %RP, or RP count. Estimation of thrombopoiesis by RP assay provides useful information for differentiation among thrombocytopenias. PMID: 12944242 [PubMed - indexed for MEDLINE] |
