High-dose intravenous gammaglobulin therapy of refractory, in particular idiopathic thrombocytopenia in childhood.

Imbach P, Barandun S, Baumgartner C, Hirt A, Hofer F, Wagner HP.
Helv Paediatr Acta. 1981 Feb;36(1):81-6.
A new immunoglobulin (Ig) for intravenous use was given in high doses to 4 children with refractory idiopathic thrombocytopenic purpura (ITP) and 2 children with idiopathic aplastic anemia (IAA). Within 5-10 days after initiation of Ig therapy the platelets of the children with ITP rose to 300,000-650,000/mm3 and could be maintained at normal levels with one Ig infusion every 1-3 weeks. No reaction was observed in the 2 patients with IAA.

PMID: 6785258 [PubMed - indexed for MEDLINE]