Systematic review of intravenous immunoglobulin in haemolytic disease of the newborn.

Gottstein R, Cooke RW.
Arch Dis Child Fetal Neonatal Ed. 2003 Jan;88(1):F6-10.

Neonatal Unit, Liverpool Women's Hospital, UK. This e-mail address is being protected from spambots. You need JavaScript enabled to view it

OBJECTIVES: To assess the effectiveness of high dose intravenous immunoglobulin (HDIVIG) in reducing the need for exchange transfusion in neonates with proven haemolytic disease due to Rh and/or ABO incompatibility. To assess the effectiveness of HDIVIG in reducing the duration of phototherapy and hospital stay. DESIGN: Systematic review of randomised and quasi-randomised controlled trials comparing HDIVIG and phototherapy with phototherapy alone in neonates with Rh and/or ABO incompatibility. RESULTS: Significantly fewer infants required exchange transfusion in the HDIVIG group (relative risk (RR) 0.28 (95% confidence interval (CI) 0.17 to 0.47); number needed to treat 2.7 (95% CI 2.0 to 3.8)). Also hospital stay and duration of phototherapy were significantly reduced. CONCLUSION: HDIVIG is an effective treatment.

Publication Types:

• Review
• Review, Academic