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High-dose intravenous gammaglobulin therapy for neonatal immune haemolytic jaundice due to blood gro

High-dose intravenous gammaglobulin therapy for neonatal immune haemolytic jaundice due to blood group incompatibility.

Sato K, Hara T, Kondo T, Iwao H, Honda S, Ueda K.
Acta Paediatr Scand. 1991 Feb;80(2):163-6.


Department of Neonatology, Medical Center for Sick Children and Infectious Disease, Fukuoka, Japan.

Three newborn infants who developed hyperbilirubinemia due to blood group incompatibility were treated with high-dose gammaglobulin. Hyperbilirubinemia was caused by Rhesus (Rh) incompatibility (anti-E + anti-c) in Infant 1 and ABO incompatibility (anti-B) in Infants 2 and 3. Hyperbilirubinemia was refractory to conventional phototherapy but responded well to intravenous gammaglobulin (IVGG) at a dose of 1 g/kg in all infants. No adverse effects were observed. These findings suggest that high-dose IVGG may be useful in the treatment of hyperbilirubinemia due to isoimmune haemolytic disease resistant to phototherapy.

Publication Types:
  • Case Reports

PMID: 1709770 [PubMed - indexed for MEDLINE]