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Intravenous immune globulin in the management of severe Rh D hemolytic disease.

Obstet Gynecol Surv. 1997 Mar;52(3):193-7.


Intravenous immune globulin in the management of severe Rh D hemolytic disease.

Porter TF, Silver RM, Jackson GM, Branch DW, Scott JR.

Department of Obstetrics and Gynecology, University of Utah School of Medicine, Salt Lake City 84132, USA.

Although intrauterine fetal transfusion has improved dramatically perinatal outcome in Rh D alloimmunization, in some cases the fetus is affected before transfusion is possible. Immune globulin (IVIG) administration is being increasingly used to successfully treat a variety of immune-mediated diseases, such as pregnancies affected by platelet alloimmunization. Although only a limited number of pregnancies have been reported, favorable outcomes with IVIG treatment of severe Rh disease have been described. We present a case report, review the published experience with IVIG treatment in severe, early-onset anti-D sensitization, and propose that IVIG may have an adjunctive role in the treatment of severe Rh isoimmunization.

Publication Types:
  • Case Reports
  • Review
  • Review of Reported Cases

PMID: 9061721 [PubMed - indexed for MEDLINE]