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Immune system modulation in the highly sensitized transplant candidate.

Immune system modulation in the highly sensitized transplant candidate.

Davidson BT, Donaldson TA.
Crit Care Nurs Q. 2004 Jan-Mar;27(1):1-9.

Vanderbilt University Medical Center, Vanderbilt University School of Nursing, Nashville, Tenn, USA.

Heart transplantation can be a lifesaving option for patients with end-stage heart failure. However, implanting recipients with an organ or tissue from a donor presents immunologic challenges. Sensitized recipients are at risk for hyperacute rejection because of the presence of preformed antibodies. Immune modulation with cyclophosphamide, plasmapheresis, and intravenous gamma globulin are methods used to desensitize transplant candidates with preformed anti-HLA antibodies to achieve successful transplantation.

Publication Types:
  • Case Reports
  • Review
  • Review, Tutorial

PMID: 14974520 [PubMed - indexed for MEDLINE]
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